Key result
Sex and blood pressure measurement methods significantly impacted genetic association signals, with top SNPs showing opposite directions of effect for the same allele in men and women.
Why the study?
Do sex and method of blood pressure measurement impact genetic associations with blood pressure in untreated adults?
Population
1550 adults aged 25-74 years, not on any antihypertensive treatment, resident in Monza, Italy (PAMELA study)
Design
Cross-sectional
Authors
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Supports stratification by sex and BP method in future genetic studies; leaves open implications for clinical risk prediction.
Observational (n=1,550)
No
Do sex and method of blood pressure measurement impact genetic associations with blood pressure in untreated adults?
Sex and blood pressure measurement methods significantly impact genetic association signals, highlighting the need to account for these factors in cardiovascular genetic studies.
Padmanabhan et al. (2010) conducted an observational in Blood pressure (n=1,550). Sex and blood pressure measurement methods was evaluated on Genetic associations with blood pressure phenotypes. Sex and blood pressure measurement methods significantly impacted genetic association signals, with top SNPs showing opposite directions of effect for the same allele in men and women.
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