Key result
Six individual genetic variants in adrenergic and renal pathways significantly affected blood pressure and demonstrated distinct gene-by-gender interactions in males and females.
Why the study?
Do genetic variants in adrenergic and renal pathways have gender-specific associations with blood pressure extremes in white Americans?
Population
1,267 age-matched white Americans within the top and bottom 5th percentiles of blood pressure, selected from…
Design
Case-control
Authors
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May identify gender-specific hypertension subgroups; hypothesis-generating and requires validation before clinical application.
Observational (n=1,267)
Do genetic variants in adrenergic and renal pathways have gender-specific associations with blood pressure extremes in white Americans?
Genetic variants in adrenergic and renal pathways exhibit significant gender-specific effects on blood pressure, suggesting distinct etiologic subgroups in essential hypertension.
Rana et al. (2006) conducted an observational in Blood pressure extremes (n=1,267). Single nucleotide polymorphisms in adrenergic and renal pathways was evaluated on Association of single nucleotide polymorphisms with blood pressure and gene-by-gender interactions. Six individual genetic variants in adrenergic and renal pathways significantly affected blood pressure and demonstrated distinct gene-by-gender interactions in males and females.
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