January 1, 2000Journal of Vascular Research
Reactive Oxygen Species and Acute Modulation of Albumin Microvascular Leakage in the Microcirculation of Diabetic Rats in vivo
Key result
Simultaneous administration of superoxide dismutase and catalase significantly inhibited the diabetes-induced increase in albumin extravasation at 1 hour (2.11 +/- 0.61 AU vs 5.28 +/- 1.29 AU).
Why the study?
Does simultaneous administration of superoxide dismutase and catalase reduce albumin microvascular leakage in diabetic rats?
Population
Diabetic rats and normoglycemic control rats
Comparison
Superoxide dismutase and catalase, administered… vs Untreated diabetic rats and normoglycemic…
Design
Preclinical
Follow-up
1 hour
Authors
Discussion
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Implication
Implicates reactive oxygen species in early diabetic microvascular leak; hypothesis-generating and should not yet change practice.
Structured PICO
Does simultaneous administration of superoxide dismutase and catalase reduce albumin microvascular leakage in diabetic rats?
P
Population
Diabetic and normoglycemic rats evaluated for albumin microvascular leakage in the cremaster muscle.
I
Intervention
Superoxide dismutase (SOD) and catalase, administered separately or simultaneously
C
Comparator
Untreated diabetic rats and normoglycemic control rats
O
Outcome
Albumin microvascular leakage (extravasation of FITC-albumin) in the cremaster muscle measured for 1 hsurrogate
Main Result
Absolute Event Rate: 2.11% vs 5.28%
Simultaneous administration of superoxide dismutase and catalase prevents diabetes-induced increases in microvascular permeability in rats, suggesting a role for reactive oxygen species.
Cite This Study
Bonnardel-Phu et al. (2000) studied Diabetes. Superoxide dismutase (SOD) and catalase vs. Untreated diabetic rats was evaluated on Extravasation of a fluorescent macromolecular tracer (FITC-albumin) at 1 h. Simultaneous administration of superoxide dismutase and catalase significantly inhibited the diabetes-induced increase in albumin extravasation at 1 hour (2.11 +/- 0.61 AU vs 5.28 +/- 1.29 AU).