Occurrence of Soluble Antigen in the Plasma of Mice With Virus-Induced Leukemia
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Why the study?
Does infective plasma from mice with virus-induced leukemia contain a soluble antigen that sensitizes cells to specific antisera?
Population
Inbred mice and transplanted leukemia cell lines used as models for virus-induced leukemia.
Comparison
Incubation of indicator leukemia cells in… vs Incubation of indicator leukemia cells in normal…
Design
Preclinical
Follow-up
up to 110 days
Authors
Discussion
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Implication
Offers insight into viral antigen behavior in leukemia; leaves open diagnostic or therapeutic relevance in humans.
Structured PICO
Does infective plasma from mice with virus-induced leukemia contain a soluble antigen that sensitizes cells to specific antisera?
P
Population
Inbred mice (BALB/c, C57BL/6, C3H, etc.) and transplanted leukemia cell lines (e.g., ERLD, EL4) used as models for virus-induced leukemia (Rauscher, Friend, Moloney, or Gross viruses).
I
Intervention
Incubation of indicator leukemia cells in infective plasma from mice with Rauscher, Friend, or Moloney virus-induced leukemia.
C
Comparator
Incubation of indicator leukemia cells in normal plasma or plasma from mice with Gross leukemia.
O
Outcome
Sensitization of indicator cells to lysis by specific antisera, measured as the percentage of dead cells in a cytotoxic test.surrogate
This preclinical study identifies a soluble viral antigen in the plasma of leukemic mice that can adsorb to cells and confer sensitivity to cytotoxic antibodies, providing insight into the immunology of virus-induced leukemias.
Cite This Study
Stück et al. (1964) studied this question.
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