SOX1 autoantibody-associated optic neuritis: Coincidence or correlation?

Anti-Sry-like high mobility group box (SOX) 1 antibodies are the antibodies associated with paraneoplastic neurological disorders with the background of small-cell lung carcinoma. The most common of these paraneoplastic disorders are Lambert–Eaton myasthenic syndrome, cerebellar degeneration, and limbic encephalitis. Here, we report a novel case of an elderly diabetic lady with optic neuritis who had an elevated erythrocyte sedimentation rate and SOX1 antibody positivity by line blot essay along with cerebellar hypometabolism in fluorodeoxyglucose positron emission tomography imaging. We also discuss the management and treatment response of the patient.