What question did this study set out to answer?

To review the cloning of the human erythropoietin gene, elucidate its structural and biological properties, and assess its clinical application for anemia.

January 1, 1986Cold Spring Harbor Symposia on Quantitative Biology

Erythropoietin: Gene Cloning, Protein Structure, and Biological Properties

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Authors

JBJeffrey K. BrowneAmgen (United States)ACAliza CohenAmgen (United States)JEJoan C. EgrieAmgen (United States)

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Implication

Scientific review demonstrates the structure and biological activity of recombinant erythropoietin, indicating its therapeutic potential for treating various anemias.

Key Points

To review the cloning of the human erythropoietin gene, elucidate its structural and biological properties, and assess its clinical application for anemia.
Cloning and characterization of the human erythropoietin gene to define its genetic organization and primary protein structure.
In vitro and in vivo biological characterization of recombinant-DNA-produced human erythropoietin (r-hEPO).
Gene cloning revealed the precise genetic sequence and molecular structure of human erythropoietin.
Preclinical evaluations demonstrated potent erythropoietic activity, leading to initial clinical trials for anemia therapy.

Cite This Study

Browne et al. (1986) studied this question.

synapsesocial.com/papers/6a9160ff1ff55ae0aec65cea https://doi.org/10.1101/sqb.1986.051.01.082

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Implication

Scientific review demonstrates the structure and biological activity of recombinant erythropoietin, indicating its therapeutic potential for treating various anemias.

Erythropoietin: Gene Cloning, Protein Structure, and Biological Properties

Discussion

Member takes

Implication

Key Points

Cite This Study

Erythropoietin: Gene Cloning, Protein Structure, and Biological Properties

Discussion

Member takes

Implication

Key Points

Cite This Study

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