Allopurinol in the Treatment of Gout

Editorials1 April 1965Allopurinol in the Treatment of GoutJAMES B. WYNGAARDEN, M.D., R. WAYNE RUNDLES, M.D., EARL N. METZ, M.D.JAMES B. WYNGAARDEN, M.D.Search for more papers by this author, R. WAYNE RUNDLES, M.D.Search for more papers by this author, EARL N. METZ, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-4-842 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElsewhere in this journal appear four papers on various aspects of gout. One by Malawista and Seegmiller represents a further study on the role of crystals of sodium urate in the pathogenesis of the acute attack, and of the effect of colchicine upon the inflammatory process. A second paper by Kaplan, Bernstein, Wallace, and Halberstam reports the presence of hyperamino-acidemia in hyperuricemic subjects and raises some questions concerning the fundamental metabolic disturbance of primary gout. A third paper by Gonick, Rubini, Gleason, and Sommers adds to our knowledge and mystery about the nature of the renal complications of gout. A...References1. HALL A: Personal communication, 1964. Google Scholar2. GUTMAN AB: Urate lithiasis in primary and secondary gout. Ann. Intern. Med. 58: 741, 1963. LinkGoogle Scholar3. PETERSVAN SLYKE JPDD: Quantitative Clinical Chemistry. Williams and Wilkins, Baltimore, 1946. Google Scholar4. GUTMANYU ABTF: Protracted uricosuric therapy in tophaceous gout. Lancet 2: 1258, 1957. CrossrefGoogle Scholar5. THOMPSONDUFFROBINSONMIKKELSENGALINDEZ GRIFWDWMH: Long term uricosuric therapy in gout. Arthritis Rheum. 5: 384, 1962. CrossrefMedlineGoogle Scholar6. TALBOTT JH: Gout. 2nd ed. Grune & Stratton, New York, 1964. Google Scholar7. WYNGAARDENRUNDLESSILBERMANHUNTER JBRWHRS: Control of hyperuricemia with hydroxypyrazolopyrimidine, a purine analogue which inhibits uric acid synthesis. Arthritis Rheum. 6: 306, 1963. Google Scholar8. RUNDLESWYNGAARDENHITCHINGSELIONSILBERMAN RWJBGHGBHR: Effects of a xanthine oxidase inhibitor on thiopurine metabolism, hyperuricemia and gout. Trans. Ass. Amer. Physicians 76: 126, 1963. Google Scholar9. YUGUTMAN TFAB Effect of allopurinol (4-hydroxypyrazolo(3,4-d)-pyrimidine) on serum and urinary uric acid in primary and secondary gout. Amer. J. Med. 37: 885, 1964. CrossrefMedlineGoogle Scholar10. POMALESBIEBERFRIEDMANHITCHINGS RSRGH: Augmentation of the incorporation of hypoxanthine into nucleic acids by the administration of an inhibitor of xanthine oxidase. Biochem. Biophys. Acta 72: 119, 1963. CrossrefMedlineGoogle Scholar11. CASKEYASHTONWYNGAARDEN CTDMJB: The enzymology of feedback inhibition of glutamine phosphoribosylpyrophosphate amidotransferase by purine ribonucleotides. J. Biol. Chem. 239: 2570, 1964. CrossrefMedlineGoogle Scholar12. MCCOLLISTERGILBERTASHTONWYNGAARDEN RJWRDMJB: Pseudofeedback inhibition of purine synthesis by 6-mercaptopurine ribonucleotide and other purine analogues. Ibid. p. 1560. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySafety of allopurinol compared with other urate-lowering drugs in patients with gout: a systematic review and meta-analysisSafety of Urate-Lowering TherapiesTreatment of Crystal Arthropathy—History and AdvancesMedikamentöse Beeinflussung von Synthese und Abbau der PurineHyperuricemia and GoutGoutNormalization of Depressed Heart Function in Rats by RiboseDrug therapy (3): ‘specific’ drugsControl of HyperuricemiaDauertherapieUric Acid Metabolism in ManZur Beeinflussung der Purin- und Pyrimidinsynthese durch AllopurinolThe Leukemias and LymphomasKlinische Aspekte der VererbungLa Terapia Medica Della Calcolosi Urica UrinariaEffect of allopurinol and oxipurinol on pyrimidine synthesis in cultured human fibroblastsDer unterschiedliche Einflu� von Allopurinol auf die endogene und exogene UratquoteBiosynthesis of uric acid in the tunicate, Molgula manhattensis, with a general scheme for the function of stored purines in animalsVasculitis with allopurinol therapyHypoxanthine-Guanine Phosphoribosyltransferase Deficiency in GoutWILLIAM N. KELLEY, M.D., MARTIN L. GREENE, M.D., FREDERICK M. ROSENBLOOM, M.D., J. FRANK HENDERSON, PH.D., J. E. SEEGMILLER, M.D.Xanthinuria, psoriasis and arthritisBasic Sciences in Medicine: The Example of GoutPyrazoles I. Synthesis of 4-Hydroxpyrazolo[3,4-d]-v-triazine A New Analog of HypoxanthineETIOLOGY AND TREATMENT OF GOUT-MODERN CONCEPTSSulla Prevenzione Delle Calcolosi Da Acido Urico Con AllopurinoloAn Enzymatic Basis for Variation in Response to AllopurinolTreatment of Uric Acid Urolithiasis With Allopurinol: A Xanthine Oxidase InhibitorSPECIAL PROBLEMS IN TOXICITYMetabolism of Oxypurines In ManTHE KIDNEY IN HEPATIC DISEASE AND IN GOUT: CLINICAL AND PATHOLOGIC ASPECTSMetabolic and therapeutic effects of allopurinol in patients with leukemia and goutSymposium on Gout and other Disorders of Purine MetabolismUse of Allopurinol for Prevention and Control of Hyperuricemia in Patients with Neoplastic Disease 1 April 1965Volume 62, Issue 4Page: 842-847KeywordsAllopurinolColchicineGoutPathogenesisUric acid Issue Published: 1 April 1965 PDF DownloadLoading ...