Synthesis of β-Substituted-butenolides through the Palladium-Catalysed Reaction of Unsaturated Triflates and Halides with Methyl 4-Hydroxy-2-butenoate

All articles of this category The palladium-catalysed reaction of unsaturated triflates and iodides with methyl-4-hydroxy-2-butenoate in the presence of KOAc and Pd(OAc) 2 affords β-vinyl- and β-aryl-butenolides through an in situ vinylic substitution/annulation sequence. The use of KOAc proved to be superior both to tertiary amines and to carbonate or bicarbonate bases in the presence of n -Bu 4 NCl. butenolides - palladium catalysis - vinylic substitution - annulation - triflates - halides