Centella Asiatica in the Conservative Treatment of Anal Fissure and Hemorrhoids in Comparison with Flavonoids

In this review we report effects Centella asiatica (Ca) in comparison with Flavonoids (Fs) to find out which best deals with healing time, bleeding and pain in the treatment of outpatients with chronic Anal Fissure (AF) on one hand. On the other hand, we report also the time-to-stop bleeding, and the anal irritation in patients who complained of Hemorrhoidal Disease (HD). Ninety-eight outpatients with AF were divided randomly into treated (either Fs or Ca) and control group. The control group (Group C, n=32) received the traditional treatment along with the other two subgroups which were treated, additionally, with Fs (Group A, n=30) or Ca (Group B, n=36). Patients were observed once weekly over 8 consecutive weeks. In another study, 130 patients with HD were studied for bleeding and pain after hemorrhoidectomy (31 patients) and hemorrhoidal thrombosis (34 patients) in the short time (II). The treated group (both conservative and surgical) was divided into two subgroups: one treated with Fs (Group A, n = 73), the other with Ca (Group B, n = 66). Sixty patients were randomized to receive the routine treatment (both conservative and surgical) (control Group C). Time-to-stop bleeding was checked at baseline and checkups (0 up to day 42).