Key result
Genetic variability in the ET-1 and EDNRA genes was described in relation to clinical and plasmatic biochemical variability in hypertensive patients, though no quantitative results were reported.
Why the study?
Are polymorphisms in the ET-1 and EDNRA genes associated with plasmatic biochemical and clinical variability in hypertensive patients?
Observational
Are polymorphisms in the ET-1 and EDNRA genes associated with plasmatic biochemical and clinical variability in hypertensive patients?
Answers are grounded in this paper and cite their sources.
This pilot study investigates the association between genetic polymorphisms in the endothelin axis and clinical/biochemical variability in hypertensive patients.
Aims: Endothelin-1 (ET-1) is a potent vasoconstrictive peptide, and its activity is mediated by the type A receptor (EDNR A ). This action may play a significant role in the etiology of hypertension. There are different works that shows an association between certain polymorphisms of endothelin axis and clinical phenotype of hypertension. We describe the genetic variability +138/ex1 Short Research Article insertion/deletion (I/D) adenosine (A) in the ET-1 gene and polymorphism thymidine/cytosine (T/C) His323His in the EDNR A gene associated at the clinical variability in hypertensive patients.
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Lassen et al. (2015) conducted an observational in Hypertension. Polymorphisms in the ET-1 and EDNRA genes was evaluated on Clinical and plasmatic biochemical variability. Genetic variability in the ET-1 and EDNRA genes was described in relation to clinical and plasmatic biochemical variability in hypertensive patients, though no quantitative results were reported.
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