Key result
Variants in the endothelin-1 and endothelin-2 genes were significantly associated with quantitative measurements of blood pressure, despite no difference in variant frequency between groups.
Why the study?
Are variants in the ET-1, ET-2, and ET(A) receptor genes associated with essential hypertension and blood pressure levels in untreated hypertensive patients compared to matched controls?
Case-Control
Are variants in the ET-1, ET-2, and ET(A) receptor genes associated with essential hypertension and blood pressure levels in untreated hypertensive patients compared to matched controls?
Polymorphisms in ET-1 and ET-2 genes are associated with quantitative differences in blood pressure, highlighting their potential role in essential hypertension.
Answers are grounded in this paper and cite their sources.
Should not change hypertension management; leaves open a role for ET-1/ET-2 variants in blood pressure regulation.
The genes for endothelin (ET) and their receptors are candidates for essential hypertension. Those for ET-1, ET-2 and the ET(A) receptor were selected for mutation scanning, and associated studies comparing untreated hypertensive patients and matched controls. A number of silent polymorphisms were found, resulting from a single nucleotide insertion or a single nucleotide substitution. There were no significant differences in the frequency of any one of these between the two groups. However, for ET-1 and ET-2 there were significant differences in the quantitative measurements of blood pressure and the number of variant alleles. The variants which we have found are likely to be in linkage disequilibrium with so far undiscovered variants in the regulatory regions of the genes.
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Brown et al. (2000) conducted a case-control in Essential hypertension. Variants of the Endothelin-1 and Endothelin-2 genes vs. Matched controls (without hypertension) was evaluated on Frequency of silent polymorphisms and quantitative measurements of blood pressure. Variants in the endothelin-1 and endothelin-2 genes were significantly associated with quantitative measurements of blood pressure, despite no difference in variant frequency between groups.
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