Key result
Weight-adjusted unfractionated heparin nomograms achieve therapeutic aPTT more rapidly than standard dosing, but inconsistencies and unpredictable therapeutic levels remain significant limitations.
Why the study?
Do weight-adjusted unfractionated heparin dosing nomograms achieve therapeutic aPTT more rapidly than standard dosing in patients with venous and arterial thrombosis?
Do weight-adjusted unfractionated heparin dosing nomograms achieve therapeutic aPTT more rapidly than standard dosing in patients with venous and arterial thrombosis?
Although weight-adjusted UFH nomograms improve the speed of achieving therapeutic aPTT compared to standard dosing, their practical limitations and inconsistencies highlight the need for more predictable anticoagulants.
Weight-adjusted UFH nomograms may hasten therapeutic aPTT yet inconsistencies limit reliability; leaves open need for more predictable anticoagulants.
Weight-adjusted nomograms have been a significant advance in the use of unfractionated heparin (UFH). Clinical trials have demonstrated the ability of weight-adjusted nomograms to achieve a therapeutic activated partial thromboplastin time (aPTT) more rapidly than with standard UFH dosing. Despite this advantage, a significant number of patients have subtherapeutic and supratherapeutic aPTTs. Real-world experiences also corroborate the inability to keep UFH therapeutic with the use of nomograms. Despite the limitations of UFH nomograms, they have been used in several different types of venous and arterial thrombosis treatment settings. Unfortunately, these nomograms are not all consistent and require a considerable amount of time for training health care professionals on their use in order to limit the potential for medication errors. Although UFH nomograms have provided advancement over standard UFH dosing, their limitations still generate the desire for a more predictable anticoagulant.
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Paul P. Dobesh (2004) conducted a review in Venous and arterial thrombosis. Weight-adjusted unfractionated heparin (UFH) nomograms vs. Standard UFH dosing was evaluated on Therapeutic activated partial thromboplastin time (aPTT). Weight-adjusted unfractionated heparin nomograms achieve therapeutic aPTT more rapidly than standard dosing, but inconsistencies and unpredictable therapeutic levels remain significant limitations.
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