Key result
The prothrombin A19911G polymorphism was associated with an increased risk of venous thromboembolism.
Why the study?
A comprehensive synthesis of evidence regarding the association between the prothrombin A19911G polymorphism and the risk of venous thromboembolism was needed.
Does the prothrombin A19911G polymorphism increase the risk of venous thromboembolism?
Meta-Analysis (n=14,001)
Does the prothrombin A19911G polymorphism increase the risk of venous thromboembolism?
Answers are grounded in this paper and cite their sources.
The prothrombin A19911G polymorphism is significantly associated with an increased susceptibility to venous thromboembolism.
Background The study employed meta-analysis to provide a comprehensive synthesis of evidence regarding the association between the prothrombin A19911G polymorphism and the risk of venous thromboembolism (VTE). Method The databases were searched to identify studies investigating the association between the prothrombin A19911G polymorphism and the risk of VTE. Meta-analysis was conducted using Stata 14.0 software. Results A total of five literature studies were included, involving 14,001 participants. Meta-analysis demonstrated that prothrombin A19911G polymorphism increased the risk of VTE (G vs A: OR = 1.17, 95% CI = 1.11–1.22, p < .00001; GG + AG vs AA: OR = 1.22, 95% CI = 1.13–1.31, p < .00001; GG vs AG + AA: OR = 1.23, 95% CI = 1.14–1.33, p < .00001; AG vs AA: OR = 1.15, 95% CI = 1.06–1.25, p = .0006; GG vs AA: OR = 1.34, 95% CI = 1.22–1.48, p < .00001). Conclusion The polymorphism of prothrombin A19911G enhances the susceptibility to VTE.
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Xiang et al. (2024) conducted a meta-analysis in Venous thromboembolism (VTE) (n=14,001). Prothrombin A19911G polymorphism (G allele) vs. A allele was evaluated on Risk of venous thromboembolism (OR 1.17, 95% CI 1.11-1.22, p=<0.00001). The prothrombin A19911G polymorphism was associated with an increased risk of venous thromboembolism.
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