May 1, 2000Civil War Book Review
Heritability of Angiotensin-Converting Enzyme and Angiotensinogen
Key result
Living in the United States was associated with lower heritability of AGT and ACE (18% for both) compared to living in Nigeria (77% and 67%, respectively).
Population
2,596 individuals from families studied for the genetics of hypertension, comprising 1,449 Nigerians and…
Design
Cross-sectional
Authors
Discussion
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Implication
Environmental differences in heritability caution against uniform genetic models; leaves open ancestry-environment interactions in hypertension research.
Study Design
Type
Observational (n=2,596)
Multicenter
Yes
Structured PICO
P
Population
2,596 individuals from families of African descent (1,449 Nigerians and 1,147 African Americans) evaluated for the heritability of AGT and ACE in contrasting environments.
O
Outcome
Heritability and familial aggregation of Angiotensinogen (AGT) and angiotensin I-converting enzyme (ACE)surrogate
Environmental context significantly influences the heritability of AGT and ACE, with lower familial aggregation observed in the US compared to Nigeria, which may impact the power of epidemiological studies to identify genetic effects.
Cite This Study
Cooper et al. (2000) conducted an observational in Genetics of hypertension (n=2,596). United States environment (African Americans) vs. Nigerian environment (Nigerians) was evaluated on Heritability of AGT and ACE. Living in the United States was associated with lower heritability of AGT and ACE (18% for both) compared to living in Nigeria (77% and 67%, respectively).