Key result
Positive inotropic drugs with similar effects on left ventricular pressure generation produced dissimilar changes in relaxation capability, affecting overall ventricular pump function.
Population
Buffer-perfused isolated rabbit heart preparation
Comparison
Positive inotropic drugs at doses sufficient to… vs Comparison among the four different inotropic…
Design
Preclinical
Authors
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May need to account for relaxation effects when evaluating positive inotropes; leaves open translation to human ventricular function.
The overall benefit of positive inotropic drugs on ventricular pump function depends not only on pressure generation but also on their effects on ventricular relaxation and ejection capabilities.
Slinker et al. (2000) studied this question. Positive inotropic drugs (calcium, dobutamine, EMD 57033, and CGP 48506) was evaluated on Overall cardiac pump function and relaxation capability. Positive inotropic drugs with similar effects on left ventricular pressure generation produced dissimilar changes in relaxation capability, affecting overall ventricular pump function.
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