Population
Isovolumically beating isolated rabbit hearts, buffer perfused at 30 degrees C
Comparison
Perfusion with the Ca2+ sensitizer EMD-57033 at… vs Control perfusion (0 microM EMD)
Design
Preclinical
Authors
Loading...
May support calcium sensitization for inotropy in isolated hearts; leaves open translation to clinical heart failure therapy.
In isolated rabbit hearts, the calcium sensitizer EMD-57033 acts as a potent inotrope that modestly prolongs contraction duration due to slowed relaxation without affecting diastolic tone.
Tobias et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: