Why the study?
Does EMD 57033 increase the susceptibility to wall-stress-induced ventricular arrhythmias in the isolated working rat heart?
Population
Isolated working rat heart model
Comparison
EMD 57033 (2 mumol/l) vs Baseline/control (implied)
Design
Preclinical
Authors
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May warrant caution with calcium sensitizers under high afterload; hypothesis-generating for arrhythmia safety in heart failure.
Does EMD 57033 increase the susceptibility to wall-stress-induced ventricular arrhythmias in the isolated working rat heart?
EMD 57033, a calcium-sensitizing positive inotrope, increases the susceptibility to wall-stress-induced ventricular arrhythmias in the isolated rat heart, highlighting potential safety concerns for its use in heart failure.
Evans et al. (1995) studied this question.
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