October 1, 1991Circulation ResearchOpen Access

EMD 53998 sensitizes the contractile proteins to calcium in intact ferret ventricular muscle.

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Population

Isolated ferret papillary muscles microinjected with aequorin

Comparison

EMD 53998 (5 microM) vs Elevation of extracellular calcium or baseline

Design

Preclinical

Authors

JLJ A LeeUniversity College London DADavid G. AllenUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

May support safer inotropy via calcium sensitization; hypothesis-generating in animal models, should not yet change practice.

Structured PICO

Population

Isolated ferret papillary muscles microinjected with aequorin

Intervention

EMD 53998 (5 microM)

Comparator

Elevation of extracellular calcium or baseline

Outcome

Developed tension and intracellular Ca2+ concentration (aequorin light transients)surrogate

EMD 53998 increases cardiac force production primarily by sensitizing contractile proteins to calcium, offering a mechanism for inotropy with potentially lower risk of calcium-activated arrhythmias.

Cite This Study

Lee et al. (1991) studied this question.

synapsesocial.com/papers/6a836e71c0767b5ec429ad4e https://doi.org/10.1161/01.res.69.4.927

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Ask AI

Bookmark

EMD 53998 sensitizes the contractile proteins to calcium in intact ferret ventricular muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

EMD 53998 sensitizes the contractile proteins to calcium in intact ferret ventricular muscle.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider