Population
In vitro models including guinea pig ventricular PDE III, rat ventricular cells, skinned fibers from porcine…
Comparison
EMD 53 998 (a novel thiadiazinone derivative) vs Pimobendan
Design
Preclinical
Authors
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Supports preclinical development of dual-mechanism inotropes; leaves open clinical translation and safety in humans.
EMD 53 998 is a potent inotropic agent that increases cardiac contractile force through both PDE III inhibition and calcium sensitization.
Beier et al. (1991) studied this question.
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