Population
Guinea pig myocardial preparations
Design
Preclinical
Authors
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Structural modifications in diazinones can redirect inotropic mechanisms; hypothesis-generating for selective myofilament sensitization, needs disease-model and clinical validation.
Structural changes in diazinone derivatives can shift their positive inotropic mechanism from predominant myofilament Ca2+ sensitization to enhanced cell Ca2+ loading.
Ventura et al. (1992) studied this question.
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