Population
Guinea pig and rat cardiac tissue
Comparison
Racemic cardiotonic EMD 53998 and its two… vs Comparison between the racemate and its…
Design
Preclinical
Authors
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Enantiomer separation isolates Ca2+ sensitization from PDE III inhibition; hypothesis-generating for selective inotropes in cardiac models.
The dual mechanisms of action of the cardiotonic agent EMD 53998 are stereospecific, with calcium sensitization residing in the (+)enantiomer and PDE III inhibition in the (-)enantiomer.
Lues et al. (1993) studied this question.
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