January 1, 1999The Japanese Journal of PharmacologyOpen Access

(−)-Enantiomer EMD 57439 Antagonizes the Ca2+ Sensitizing Effect of (+)-Enantiomer EMD 57033 on Diastolic Function but Not on Systolic Function in Rabbit Ventricular Cardiomyocytes

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Population

Rabbit ventricular cardiomyocytes loaded with indo-1/AM

Comparison

EMD 53998,-enantiomer EMD 57033, and-enantiomer… vs Elevation of [Ca2+]o and comparison between…

Design

Preclinical

Authors

SHSugawara HiromiYamagata University MEMasao EndohYamagata University

Discussion

Member takes

Implication

Highlights enantiomer-specific lusitropy in cardiomyocytes; leaves open whether purified EMD 57033 improves diastolic function in vivo.

Structured PICO

Population

Rabbit ventricular cardiomyocytes loaded with indo-1/AM

Intervention

EMD 53998 (racemic mixture), (+)-enantiomer EMD 57033, and (-)-enantiomer EMD 57439

Comparator

Elevation of [Ca2+]o and comparison between enantiomers

Outcome

Ca2+ transients and cell shortening (systolic and diastolic function)surrogate

The (-)-enantiomer EMD 57439 selectively antagonizes the diastolic Ca2+-sensitizing effects of the (+)-enantiomer EMD 57033 without affecting systolic function in rabbit cardiomyocytes.

Cite This Study

Hiromi et al. (1999) studied this question.

synapsesocial.com/papers/6a836e788df6316dcba9b658 https://doi.org/10.1254/jjp.80.55

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(−)-Enantiomer EMD 57439 Antagonizes the Ca2+ Sensitizing Effect of (+)-Enantiomer EMD 57033 on Diastolic Function but Not on Systolic Function in Rabbit Ventricular Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

(−)-Enantiomer EMD 57439 Antagonizes the Ca2+ Sensitizing Effect of (+)-Enantiomer EMD 57033 on Diastolic Function but Not on Systolic Function in Rabbit Ventricular Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider