October 1, 2001British Journal of PharmacologyOpen Access

Beneficial effects of the Ca2+ sensitizer EMD 57033 in exercising pigs with infarction‐induced chronic left ventricular dysfunction

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Why the study?

Does EMD 57033 improve cardiovascular performance during exercise in pigs with infarction-induced chronic left ventricular dysfunction?

Population

25 pigs of either sex, weight 23+/-1 kg. 12 with infarction-induced chronic left ventricular dysfunction…

Comparison

EMD 57033 administered intravenously. vs Pimobendan 20 mcg/kg/min IV, vehicle, and normal…

Design

Preclinical

Authors

DDDirk J. DunckerGeneral Cardiology DHDavid B. HaitsmaErasmus MC DLDavid LiemUniversity of California System

Discussion

Member takes

Implication

Does not support clinical use of EMD 57033; leaves open whether pure Ca2+ sensitization improves exercise hemodynamics in human HF.

Structured PICO

Does EMD 57033 improve cardiovascular performance during exercise in pigs with infarction-induced chronic left ventricular dysfunction?

Population

25 pigs (Land race x Yorkshire) of either sex, weight 23+/-1 kg. 12 with infarction-induced chronic left ventricular dysfunction (MI) produced by coronary artery ligation 2-3 weeks prior, and 13 normal pigs (N).

Intervention

EMD 57033 (Ca2+ sensitizer) administered intravenously (0.2 - 0.8 mg/kg/min at rest, 0.4 mg/kg/min during treadmill exercise).

Comparator

Pimobendan (mixed Ca2+-sensitizer/PDE-III inhibitor) 20 mcg/kg/min IV, vehicle (propylene glycol), and normal pigs.

Outcome

Cardiovascular performance including cardiac output, stroke volume, and LVdP/dtmax at rest and during graded treadmill exercise.surrogate

The pure Ca2+ sensitizer EMD 57033 maintains its positive inotropic effects during exercise in a porcine model of chronic LV dysfunction, unlike the mixed agent pimobendan, suggesting potential utility for inotropic support in heart failure without increasing myocardial oxygen demand.

Cite This Study

Duncker et al. (2001) studied this question.

synapsesocial.com/papers/6a75e1650294aedd57e698ce https://doi.org/10.1038/sj.bjp.0704292

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Beneficial effects of the Ca2+ sensitizer EMD 57033 in exercising pigs with infarction‐induced chronic left ventricular dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Beneficial effects of the Ca2+ sensitizer EMD 57033 in exercising pigs with infarction‐induced chronic left ventricular dysfunction

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider