Why the study?
Does EMD 57033 improve systolic and diastolic function in open-chest anaesthetized pigs with regionally stunned myocardium?
Population
Open-chest anaesthetized pigs with regionally stunned myocardium induced by 15 min coronary occlusion and 30…
Comparison
EMD 57033 (0.2 mg kg(-1) min(-1) for 60 min, i.v.) vs Vehicle (n=7)
Design
Preclinical
Follow-up
60 minutes
Authors
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Supports calcium sensitization in stunned myocardium; extends preclinical data but leaves open clinical translation.
Does EMD 57033 improve systolic and diastolic function in open-chest anaesthetized pigs with regionally stunned myocardium?
The calcium sensitizer EMD 57033 restores both systolic and diastolic function in stunned porcine myocardium without impairing relaxation.
Zeeuw et al. (2000) studied this question.
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