Why the study?
Does EMD 60263 improve function and mechanical efficiency in anesthetized pigs with stunned myocardium?
Population
Anesthetized pigs with normal or stunned myocardium (induced by LADCA occlusion and reperfusion) (n=31)
Comparison
EMD 60263 0.75 and 1.5 mg/kg i.v. administered… vs Saline infusion (3 and 6 mL)
Design
Preclinical
Authors
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Does not inform clinical use; leaves open whether calcium sensitization improves stunning in humans.
Does EMD 60263 improve function and mechanical efficiency in anesthetized pigs with stunned myocardium?
Calcium sensitization with EMD 60263 predominantly enhances the function and mechanical efficiency of stunned myocardium in vivo, supporting the hypothesis that Ca2+ desensitization is involved in myocardial stunning.
Soei et al. (1994) studied this question.
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