Why the study?
Does myocardial stunning increase the afterload dependency of mechanical efficiency, and is this attenuated by dobutamine?
Population
13 anaesthetised open thorax pigs undergoing two cycles of 10 min occlusion of left anterior descending…
Comparison
Induction of myocardial stunning and subsequent… vs Pre-stunning baseline
Design
Preclinical
Authors
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May explain variability in stunned myocardium efficiency data; leaves open clinical translation of dobutamine effects.
Does myocardial stunning increase the afterload dependency of mechanical efficiency, and is this attenuated by dobutamine?
Myocardial stunning increases the afterload dependency of mechanical efficiency, which can be attenuated by dobutamine, explaining the large variability in mechanical efficiency data of stunned myocardium.
D Fan (1995) studied this question.
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