November 1, 1997AJP Heart and Circulatory PhysiologyOpen Access

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium

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Population

Anesthetized pigs (n=9)

Comparison

Myocardial stunning induced by 5-min left… vs Baseline (normal myocardium before stunning)

Design

Preclinical

Authors

DFDongsheng FanKing University LSLoe Kie SoeiSint Franciscus Gasthuis RSRené StubenitskyErasmus University Rotterdam

Discussion

Member takes

Implication

Hypothesis-generating for nonuniformity dominating mechanical interaction post-stunning; animal data leave open clinical relevance in ischemic dysfunction.

Structured PICO

Population

Anesthetized pigs (n=9)

Intervention

Myocardial stunning induced by 5-min left circumflex coronary artery (LCX) occlusion and subsequent 10-min left anterior descending coronary artery (LAD) occlusion, with intracoronary dobutamine infusions

Comparator

Baseline (normal myocardium before stunning)

Outcome

Mechanical interaction evaluated by regional postsystolic work (PSW) and the contributions of asynchrony (delta T) and nonuniformity in contractility (delta E)surrogate

In stunned myocardium, nonuniformity in contractility becomes a more dominant factor in mechanical interaction compared to asynchrony, which predominates in normal myocardium.

Cite This Study

Fan et al. (1997) studied this question.

synapsesocial.com/papers/6a72833e5d37378ac1df436a https://doi.org/10.1152/ajpheart.1997.273.5.h2146

View Full Paper

Ask AI

Bookmark

Implication

Hypothesis-generating for nonuniformity dominating mechanical interaction post-stunning; animal data leave open clinical relevance in ischemic dysfunction.

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider