Effects of calcium and EMD-53998 on oxygen consumption in isolated canine hearts.
Why the study?
Does EMD-53998 improve myocardial efficiency compared to calcium in isolated canine hearts?
Population
6 isolated, isovolumically beating blood-perfused canine hearts paced at 120 beats per minute
Comparison
EMD-53998 infusion vs CaCl2 infusion
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
EMD-53998 shows no efficiency advantage over calcium in isolated hearts; leaves open translation to intact models or patients.
Structured PICO
Does EMD-53998 improve myocardial efficiency compared to calcium in isolated canine hearts?
P
Population
6 isolated, isovolumically beating blood-perfused canine hearts paced at 120 beats per minute
I
Intervention
EMD-53998 infusion
C
Comparator
CaCl2 infusion
O
Outcome
Myocardial oxygen consumption (MVO2) in relation to contractilitysurrogate
The calcium-sensitizing agent EMD-53998 does not provide an energetic advantage over calcium in terms of myocardial oxygen consumption in isolated canine hearts.
Cite This Study
Tombe et al. (1992) studied this question.