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May 1, 1996Clinical Pharmacology & Therapeutics

Impaired β2-adrenergic agonist–induced venodilation in Indians of Asian origin*

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Why the study?

Does venous responsiveness to beta-2 adrenergic agonists differ between young Asian Indian and white subjects?

Population

22 young subjects (11 white subjects and 11 Asian Indian subjects)

Comparison

Local infusion of the beta 2-agonist… vs White subjects

Design

Cross-sectional, Subgroup of 6 subjects in each group randomly selected for…

Authors

CKCharanjit KapoorOchsner Medical CenterCSClement SingarajahHZHaider Zafar

Discussion

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Implication

May influence beta-agonist efficacy in Asian Indians; hypothesis-generating, requiring prospective validation.

Structured PICO

Does venous responsiveness to beta-2 adrenergic agonists differ between young Asian Indian and white subjects?

P
Population
22 young subjects (11 white subjects and 11 Asian Indian subjects)
I
Intervention
Local infusion of the beta 2-agonist isoproterenol (2 to 270 ng/min) in dorsal hand veins preconstricted with phenylephrine. A randomly selected subgroup (n=6 per group) also received nitroglycerin (0.006 to 1485 ng/min).
C
Comparator
White subjects
O
Outcome
Venous responsiveness, measured as maximal response (E(max)) and log of the dose producing half-maximal venodilation (log(ED50)) to isoproterenol and nitroglycerinsurrogate

Asian Indians exhibit impaired beta-2 adrenergic receptor-mediated venodilation compared to white subjects, which may affect the efficacy of beta-adrenergic therapies in this population.

Cite This Study

Kapoor et al. (1996) studied this question.

synapsesocial.com/papers/6a9170fca97dfa43b7464852https://doi.org/10.1016/s0009-9236(96)90185-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased Responsiveness of Superficial Hand Veins to Phenylephrine in Black Normotensive Males1990 · 18 citations
  2. 2Attenuation of Isoproterenol-Mediated Vasodilatation in Blacks1995 · 162 citations
  3. 3Vascular reactivity to phenylephrine and angiotensin II: Comparison of direct venous and systemic vascular responses1992 · 31 citations
  4. 4First myocardial infarctions in Asian and white men.1989 · 159 citations
  5. 5Are There Beta-Adrenergic Receptor Response Differences between Racial Groups?1991 · 15 citations