January 1, 1992Clinical Pharmacology & Therapeutics
Vascular reactivity to phenylephrine and angiotensin II: Comparison of direct venous and systemic vascular responses
Population
Humans
Design
Other
Authors
Discussion
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Implication
Hand vein model may offer practical alternative for alpha-adrenergic assessment; leaves open validation in larger prospective studies before clinical use.
Key Points
- To evaluate the relationship between peripheral venous responsiveness measured via dorsal hand vein compliance and systemic vascular responsiveness measured via blood pressure changes to phenylephrine and angiotensin II in humans.
- Measured local peripheral venous responsiveness using the dorsal hand vein compliance technique to calculate log ED50 for phenylephrine and angiotensin II.
- Assessed systemic vascular responsiveness by measuring the dose required to produce a 20 mm increase in mean arterial pressure.
- Mean arterial pressure dose response significantly correlated with hand vein log ED50 for phenylephrine (r = 0.70, p < 0.02), whereas no correlation was observed for angiotensin II.
- Hand vein log ED50 measurements for phenylephrine and angiotensin II correlated significantly with each other (r = 0.70, p < 0.02), though their systemic vascular responses showed no correlation.
Structured PICO
P
Population
Humans
I
Intervention
Phenylephrine and angiotensin II administration
O
Outcome
Relationship between peripheral venous responsiveness (dorsal hand vein compliance technique) and systemic vascular responsiveness (blood pressure changes)surrogate
The dorsal hand vein compliance approach offers a satisfactory alternative to systemic hemodynamic changes for evaluating alpha-adrenergic receptor mediated responses.
Cite This Study
Vincent et al. (1992) studied this question.