August 1, 1990Journal of Cardiovascular Pharmacology
Decreased Responsiveness of Superficial Hand Veins to Phenylephrine in Black Normotensive Males
Why the study?
Does vascular adrenoceptor responsiveness to phenylephrine and isoproterenol differ between black and white young normotensive males?
Population
Black and white young normotensive males
Comparison
Phenylephrine and isoproterenol administration vs Comparison between racial groups
Design
Cross-sectional
Authors
Discussion
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Implication
Reduced alpha-adrenergic venoconstriction in black normotensive males should not change practice; hypothesis-generating for ethnic differences in vascular responsiveness.
Structured PICO
Does vascular adrenoceptor responsiveness to phenylephrine and isoproterenol differ between black and white young normotensive males?
P
Population
Black and white young normotensive males
I
Intervention
Phenylephrine (alpha-adrenergic agonist) and isoproterenol (beta-adrenergic agonist) administration
C
Comparator
Comparison between racial groups (black vs. white males)
O
Outcome
Diameter changes in superficial veins (maximal venoconstriction [Emax] and ED50)surrogate
Normotensive black males show decreased maximal responsiveness to alpha-adrenergic stimulation in superficial veins compared to white males.
Cite This Study
Eichler et al. (1990) studied this question.