Key result
Black subjects demonstrated greater sensitivity to phenylephrine-induced venoconstriction compared with white subjects (geometric mean ED50 172 vs 310 ng/min; adjusted P=0.003).
Why the study?
Does sensitivity to α1-adrenoceptor-mediated venoconstriction differ between black and white subjects?
Population
106 subjects (64 whites and 42 blacks)
Comparison
Increasing doses of the selective… vs Comparison between black and white subjects
Design
Cross-sectional
Authors
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May contribute to ethnic hypertension disparities; hypothesis-generating and requires prospective validation before clinical consideration.
Cross-Sectional (n=106)
Does sensitivity to α1-adrenoceptor-mediated venoconstriction differ between black and white subjects?
Absolute Event Rate: 172% vs 310%
p-value: p=0.003
Black subjects demonstrate a generalized increased sensitivity to α1-adrenoreceptor-mediated venoconstriction compared to white subjects, which may contribute to ethnic differences in hypertension prevalence.
Adefurin et al. (2013) reported a cross-sectional. Black ethnicity vs. White ethnicity was evaluated on Dose that produced 50% of maximal constriction (ED50) to phenylephrine (p=0.003). Black subjects demonstrated greater sensitivity to phenylephrine-induced venoconstriction compared with white subjects (geometric mean ED50 172 vs 310 ng/min; adjusted P=0.003).
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