Ethnic Differences in the Vasoconstrictor Activity of Endogenous Endothelin-1 in Hypertensive Patients
Why the study?
Does intraarterial infusion of an ET(A) receptor blocker reveal ethnic differences in forearm blood flow responses in normotensive and hypertensive patients?
Population
64 patients, comprising 37 normotensive and 27 hypertensive individuals.
Comparison
Intraarterial infusion of an ET receptor… vs Comparison between black and white patients, and…
Design
Cross-sectional
Authors
Discussion
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Implication
Hypothesis-generating for enhanced ET(A) tone in black hypertensives; prospective trials needed before considering race-specific therapies.
Structured PICO
Does intraarterial infusion of an ET(A) receptor blocker reveal ethnic differences in forearm blood flow responses in normotensive and hypertensive patients?
P
Population
64 patients, comprising 37 normotensive (22 white, 15 black) and 27 hypertensive (14 white, 13 black) individuals.
I
Intervention
Intraarterial infusion of an ET(A) receptor blocker (BQ-123). Subgroups also received exogenous ET-1 or co-infusion of BQ-123 and BQ-788.
C
Comparator
Comparison between black and white patients, and between normotensive and hypertensive patients.
O
Outcome
Forearm blood flow (FBF) responses analyzed by plethysmography.surrogate
Hypertensive black patients exhibit enhanced ET(A)-dependent vasoconstrictor tone compared to white patients, suggesting a potential mechanism for ethnic differences in the pathogenesis of hypertension.
Cite This Study
Campia et al. (2004) studied this question.