Key result
African American race is linked to ~3-fold higher saphenous vein ECE-1a and elevated preproET-1 expression.
Why the study?
Whether the molecular components of vascular ET-1 biosynthesis and function are altered in African American hypertensive patients compared to white hypertensive patients was not established.
Are the molecular components of vascular ET-1 biosynthesis and function altered in African American patients compared to white patients?
Comparison
African American race vs white race
Design
Cross-sectional study
Authors
Loading...
Racial differences in vascular ET-1 biosynthesis may contribute to hypertension disparities; hypothesis-generating for race-specific ET pathway targeting.
Cross-Sectional (n=28)
Are the molecular components of vascular ET-1 biosynthesis and function altered in African American patients compared to white patients?
The biosynthetic pathway of ET-1 is activated to a higher degree and ET(B) receptor expression is altered in the peripheral vasculature of African American patients, which may contribute to the increased incidence of hypertension in this population.
Grubbs et al. (2002) conducted a cross-sectional in Hypertension and coronary artery disease (n=28). African American race vs. White race was evaluated on Vascular mRNA and protein levels of ECE-1 subisoforms, ET-1, and ET receptor profiles. African American race was associated with an approximately 2- and 3-fold upregulation of preproET-1 and ECE-1a expression, respectively, in saphenous veins compared to white patients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: