Key result
Intracoronary infusion of ET-1 decreased coronary blood flow per unit of interstitial space by approximately 30% (P=0.006) and increased myocardial microcirculatory transit times.
Why the study?
Does intracoronary infusion of endothelin-1 affect coronary microcirculatory exchanges and myocardial metabolism in anesthetized dogs?
Population
Anesthetized dogs (n=12 for extraction study, n=6 for infusion study)
Design
Preclinical
Authors
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May impair canine myocardial metabolism via reduced microcirculatory flow; leaves open endothelin’s role in human coronary dysfunction.
Does intracoronary infusion of endothelin-1 affect coronary microcirculatory exchanges and myocardial metabolism in anesthetized dogs?
Effect estimate: decreased by approximately 30%
p-value: p=0.006
Pharmacological doses of endothelin-1 may adversely affect myocardial metabolism by reducing blood flow and capillary permeability for small circulating substances.
Dupuis et al. (1997) studied this question. Intracoronary infusion of endothelin-1 (ET-1) was evaluated on Coronary blood flow per unit of interstitial space (decreased by approximately 30%, p=0.006). Intracoronary infusion of ET-1 decreased coronary blood flow per unit of interstitial space by approximately 30% (P=0.006) and increased myocardial microcirculatory transit times.
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