March 1, 2003The Journal of Clinical Pharmacology
Reproducibility of Dorsal Hand Vein Responses to Phenylephrine and Prostaglandin F2α Using the Dorsal Hand Vein Compliance Method
Why the study?
What is the intra- and intersubject reproducibility of dorsal hand vein responses to phenylephrine and prostaglandin F2 alpha?
Population
12 healthy male nonsmokers
Comparison
Phenylephrine and prostaglandin F2 alpha… vs Intra- and intersubject comparison on different…
Design
Other
Follow-up
100 minutes
Authors
Discussion
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Member takes
Implication
May support phenylephrine preference in hand vein studies; leaves open need for prospective confirmation.
Structured PICO
What is the intra- and intersubject reproducibility of dorsal hand vein responses to phenylephrine and prostaglandin F2 alpha?
P
Population
12 healthy male nonsmokers
I
Intervention
Phenylephrine and prostaglandin F2 alpha (PGF2 alpha) infusion to achieve approximately 80% constriction of the vein (ED80) for 100 minutes
C
Comparator
Intra- and intersubject comparison on different study days
O
Outcome
Intra- and intersubject reproducibility of the venous preconstriction technique (coefficient of variation of ED80) and influence of basal vein sizesurrogate
Phenylephrine is a more reliable tool than prostaglandin F2 alpha for studying dilatory responses in preconstricted hand veins because its effects are independent of basal vein diameter.
Cite This Study
Schindler et al. (2003) studied this question.