Why the study?
Do superficial hand and foot veins show different sensitivity to constrictor agents in healthy male volunteers?
Population
17 healthy male volunteers (5 for norepinephrine study, 12 for dihydroergotamine study)
Comparison
Locally infused norepinephrine or intramuscular… vs Placebo (for the dihydroergotamine group)
Design
RCT, randomized order, double-blind
Authors
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Validates hand veins as representative of other superficial veins for constrictor studies; extends dorsal hand vein model applicability in venous pharmacology research.
Do superficial hand and foot veins show different sensitivity to constrictor agents in healthy male volunteers?
Superficial hand and foot veins exhibit similar responsiveness to constrictor agents despite differences in hydrostatic pressure, suggesting hand veins are representative of superficial veins elsewhere.
W. H. Aellig (1990) studied this question.
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