What question did this study set out to answer?

To review the physiological characteristics, in vivo measurement methodologies, pathophysiological alterations, and pharmacological responsiveness of human superficial veins.

September 1, 1994British Journal of Clinical PharmacologyOpen Access

Clinical pharmacology, physiology and pathophysiology of superficial veins‐1.

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Design

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Authors

WAWH AelligSanden (Japan)

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Implication

Supports venous research applications; leaves open clinical standardization and adoption.

Key Points

To review the physiological characteristics, in vivo measurement methodologies, pathophysiological alterations, and pharmacological responsiveness of human superficial veins.
Evaluated systemic peripheral venous assessment using venous occlusion plethysmography to simultaneously record arterial flow and venous compliance.
Assessed localized compliance in single superficial veins in vivo across healthy volunteers, twin cohorts, and diverse clinical patient groups using a linear variable differential transformer (LVDT) under standardized congestion pressures.
Venoconstriction was provoked by local exposure to alpha-adrenoceptor agonists, 5-HT-receptor agonists, ergot derivatives, angiotensin peptides, and specific prostaglandins.
Venodilation was detectable in preconstricted veins upon administration of beta-adrenoceptor agonists, muscarinic agonists, nitrates, calcium channel blockers, bradykinin, and substance P.
Venous compliance and reactivity were modified by physiological variables (age, exercise, temperature, menstrual cycle) and altered in disorders such as hypertension, orthostatic hypotension, diabetes, and varicosis.

Cite This Study

WH Aellig (1994) studied this question.

synapsesocial.com/papers/6a88439b5ee6e03ae3cf1a46 https://doi.org/10.1111/j.1365-2125.1994.tb04341.x

Topics

Hypertension management Women and heart disease

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Clinical pharmacology, physiology and pathophysiology of superficial veins‐1.

Discussion

Member takes

Implication

Key Points

Cite This Study

Topics

Clinical pharmacology, physiology and pathophysiology of superficial veins‐1.

Discussion

Member takes

Implication

Key Points

Cite This Study

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