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May 1, 1987British Journal of Clinical PharmacologyOpen Access

A pragmatic approach to the pressor dose‐response as an index of vascular reactivity and adrenoceptor function in man.

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Why the study?

What is the optimal infusion duration to achieve steady state blood pressure and heart rate responses for different vasoactive drugs in normotensive males?

Population

Normotensive males

Design

Other

Authors

DSDJ SumnerStobhill HospitalHEHL ElliottUniversity of AlbertaJVJohn VincentHeart Failure / Cardiomyopathy

Discussion

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Implication

Infusion times to steady state vary by agent; leaves open validation for study design in patients or other populations.

Structured PICO

What is the optimal infusion duration to achieve steady state blood pressure and heart rate responses for different vasoactive drugs in normotensive males?

P
Population
Normotensive males
I
Intervention
Constant infusions of incremental doses of vasoactive drugs (noradrenaline, alpha-methyl noradrenaline, phenylephrine, isoprenaline)
O
Outcome
Time to achieve steady state responses for blood pressure and heart rate increasessurrogate

The time required to achieve steady-state pressor responses varies by vasoactive drug and correlates with the half-life of the agonist's offset effect, informing the design of clinical pharmacological studies.

Cite This Study

Sumner et al. (1987) studied this question.

synapsesocial.com/papers/6a9170fca97dfa43b7464856https://doi.org/10.1111/j.1365-2125.1987.tb03085.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of Adrenaline upon Cardiovascular and Metabolic Functions in Man1985 · 106 citations
  2. 2Comparison of fast and slow pressor effects of angiotensin II in the conscious rat1981 · 96 citations
  3. 3Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man.1980 · 582 citations
  4. 4Adrenaline and Hypertension1984 · 29 citations
  5. 5Analysis of the pressor dose response1982 · 45 citations