Key result
EMD 57033 increased maximal calcium-activated force by 228% in fibres with cardiac TnC compared to 137% in fibres with fast TnC.
Population
Glycerinated, permeabilized rabbit psoas fibres with endogenous skeletal TnC extracted and replaced with…
Comparison
EMD 57033 (10 microM) vs Unextracted control fibres and comparison…
Design
Preclinical
Authors
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Highlights potential cardiac TnC selectivity for EMD 57033; leaves open translation to human myocardium or therapy.
Absolute Event Rate: 228% vs 137%
The cardiotonic agent EMD 57033 increases calcium-activated force to a greater extent in the presence of cardiac troponin C compared to skeletal troponin C.
Lipscomb et al. (2005) studied this question. EMD 57033 vs. fast TnC was evaluated on maximal calcium-activated force (Pmax). EMD 57033 increased maximal calcium-activated force by 228% in fibres with cardiac TnC compared to 137% in fibres with fast TnC.
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