Key result
Alamandine co-therapy significantly reduced doxorubicin-induced nephrotoxicity in rats, decreasing serum creatinine from 1.61 mg/dl to 1.06 mg/dl (p<0.01).
Why the study?
The objective was to evaluate the protective effects of alamandine against doxorubicin-induced nephrotoxicity in rats.
Does alamandine prevent doxorubicin-induced nephrotoxicity in rats?
Does alamandine prevent doxorubicin-induced nephrotoxicity in rats?
Absolute Event Rate: 1.06% vs 1.61%
p-value: p=<0.01
Alamandine demonstrates potential protective effects against doxorubicin-induced nephrotoxicity in a rat model.
Alamandine may attenuate doxorubicin nephrotoxicity in rats; leaves open any human therapeutic role.
Background: The objective of this study was to evaluate the protective effects of alamandine, a new member of the angiotensin family, against doxorubicin (DOX)-induced nephrotoxicity in rats.Methods: Rats, intraperitoneally injected with DOX (3.750 mg/kg/week) to reach total cumulative dose of 15 mg/kg on day 35. Alamandine (50µg/kg/day) was administered to the rats via mini-osmotic pumps for 42 days. At the end of experiment, rats were placed in the metabolic cages for 24 h for measurement of water intake and urine output. After scarification, Serum and kidney tissues were collected, and biochemical, histopathological and immunohistochemical studies were carried out.Results: Inflammatory cytokines (IL-1β, IL-6), pro-fibrotic mediator (TGF-β), pro-inflammatory transcription factor (NF-kB), renal MDA, creatinine clearance, BUN, and water intake were increased by DOX administration. On the other hand, renal SOD, renal GPx activity and urinary output were decreased in the DOX-treated group. Alamandine co-therapy decreased these effects, as confirmed by histopathology and immunohistochemical analysisConclusion: The results of this study suggest that alamandine has the potential in preventing the nephrotoxicity induced by DXR in rats.
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Hekmat et al. (2021) studied Doxorubicin-induced nephrotoxicity (n=35). Alamandine vs. Doxorubicin alone was evaluated on Serum Creatinine (mg/dl) (p=<0.01). Alamandine co-therapy significantly reduced doxorubicin-induced nephrotoxicity in rats, decreasing serum creatinine from 1.61 mg/dl to 1.06 mg/dl (p<0.01).
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