What question did this study set out to answer?

To determine whether endogenous alpha-MSH levels change during clinical infectious and inflammatory diseases and whether alpha-MSH can inhibit proinflammatory cytokine production in human blood.

May 1, 1998Annals of the New York Academy of Sciences

The Neuropeptide α‐MSH in HIV Infection and Other Disorders in Humansa

View Full Paper

Ask AI

Bookmark

To determine whether endogenous alpha-MSH levels change during clinical infectious and inflammatory diseases and whether alpha-MSH can inhibit proinflammatory cytokine production in human blood.
Measured alpha-MSH concentrations in plasma or synovial fluid across human cohorts, including patients with HIV infection, septic syndrome, arthritis, and acute myocardial infarction, alongside young and elderly controls.
Treated whole-blood samples from HIV and septic syndrome patients with alpha-MSH ex vivo to evaluate its effect on endotoxin-stimulated IL-1 and TNF production.
Circulating alpha-MSH was elevated in advanced HIV infection (CDC groups III and IV), arthritis synovial fluid, and acute myocardial infarction, but was reduced in septic syndrome and healthy elderly controls.
Ex vivo administration of alpha-MSH significantly reduced endotoxin-stimulated production of proinflammatory IL-1 and TNF in whole-blood samples from both HIV and septic syndrome patients.

Authors

ACAnna CataniaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico LALorena AiraghiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico LGLetizia GarofaloUniversity of Milan

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Observational study reveals altered alpha-MSH levels across inflammatory disorders and anti-inflammatory actions, highlighting its therapeutic potential.

Cite This Study

Catania et al. (1998) studied this question.

synapsesocial.com/papers/6a91750bd73fb5289dab5e1b https://doi.org/10.1111/j.1749-6632.1998.tb09622.x

View Full Paper

Ask AI

Bookmark

Implication

Observational study reveals altered alpha-MSH levels across inflammatory disorders and anti-inflammatory actions, highlighting its therapeutic potential.

The Neuropeptide α‐MSH in HIV Infection and Other Disorders in Humansa

Key Points

Discussion

Implication

Cite This Study

The Neuropeptide α‐MSH in HIV Infection and Other Disorders in Humansa

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider