June 30, 2012Acta Physiologica
NAD(P)H oxidase p22phox polymorphism and cardiovascular function in amateur runners
Key result
In male amateur runners, carrying the T allele of the p22(phox) C242T polymorphism (n=40) was associated with more efficient myocardial contraction, left ventricular filling, and lower arterial stiffness.
Why the study?
Does the p22(phox) C242T polymorphism influence cardiovascular function and arterial stiffness in male amateur runners?
Population
73 male amateur runners
Comparison
p22 C242T polymorphism vs CC genotype
Design
Cross-sectional
Authors
Discussion
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Implication
May support genotype-informed training in runners; hypothesis-generating and requires prospective validation before clinical use.
Study Design
Type
Cross-Sectional (n=73)
Structured PICO
Does the p22(phox) C242T polymorphism influence cardiovascular function and arterial stiffness in male amateur runners?
P
Population
73 male amateur runners screened for the CYBA p22(phox) C242T polymorphism to assess cardiovascular function.
E
Exposure
p22(phox) C242T polymorphism (T allele carriers: CT/TT)
C
Comparator
CC genotype
O
Outcome
Cardiovascular function (systolic and diastolic function, arterial stiffness) assessed by echocardiographic-Doppler examination and PulsePen tonometersurrogate
The p22(phox) 242T allele is associated with better systolic and diastolic function and lower arterial stiffness in amateur runners, possibly due to lower oxidative activity.
Cite This Study
Gallina et al. (2012) conducted a cross-sectional in Amateur runners (n=73). p22(phox) C242T polymorphism T allele vs. CC genotype was evaluated on Cardiovascular function (myocardial contraction, left ventricular filling, and arterial stiffness). In male amateur runners, carrying the T allele of the p22(phox) C242T polymorphism (n=40) was associated with more efficient myocardial contraction, left ventricular filling, and lower arterial stiffness.