Why the study?
Does the p22phox -930A/G polymorphism affect p22phox expression and NADPH oxidase activity in patients with essential hypertension?
Does the p22phox -930A/G polymorphism affect p22phox expression and NADPH oxidase activity in patients with essential hypertension?
The GG genotype of the p22phox -930A/G polymorphism is associated with increased NADPH oxidase-mediated oxidative stress in patients with essential hypertension.
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GG genotype may heighten oxidative stress in hypertension; hypothesis-generating and requires prospective validation before clinical consideration.
José et al. (2004) studied this question.
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