Key result
The p22phox C242T gene polymorphism T allele was significantly associated with an increased risk of overt diabetic nephropathy (OR 2.760).
Why the study?
Is the p22phox C242T gene polymorphism associated with an increased risk of overt diabetic nephropathy?
Meta-Analysis (n=1,452)
Is the p22phox C242T gene polymorphism associated with an increased risk of overt diabetic nephropathy?
Odds Ratio: 2.76 (95% CI 1.4–5.45)
p-value: p=0.004
The T allele of the p22phox C242T gene polymorphism is associated with an increased risk of overt diabetic nephropathy.
T allele may refine nephropathy risk stratification in diabetes; extends genetic associations but remains hypothesis-generating pending prospective validation.
BACKGROUND/AIMS: The p22phox C242T gene polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive. METHODS: To explore the relationship between p22phox C242T gene polymorphism and ODN, the current meta-analysis of 707 ODN patients and 745 controls from five individual studies was conducted. The pooled odds ratio (OR) and its corresponding 95% confidence interval (CI) were evaluated by either a random or fixed effect model. RESULTS: In our meta-analysis, a significant relationship between the p22phox C242T gene polymorphism and ODN was found under allelic (OR, 2.760; 95% CI, 1.400 to 5.450; p = 0.004), recessive (OR, 5.080; 95% CI, 1.020 to 25.430; p = 0.05), dominant (OR, 1.700; 95% CI, 1.167 to 2.477; p = 0.006), homozygous (OR, 3.900; 95% CI, 1.022 to 14.889; p = 0.046), heterozygous (OR, 1.523; 95% CI, 1.167 to 1.986; p = 0.002), and additive genetic models (OR, 2.019; 95% CI, 1.232 to 3.309; p = 0.005). CONCLUSIONS: A positive correlation between p22phox C242T gene polymorphism and ODN risk was found. The T allele carriers of p22phox C242T gene polymorphism might be predisposed to ODN.
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Li et al. (2016) conducted a meta-analysis in Overt diabetic nephropathy (n=1,452). p22phox C242T gene polymorphism (rs4673) vs. Controls without overt diabetic nephropathy was evaluated on Risk of overt diabetic nephropathy (allelic genetic model) (OR 2.760, 95% CI 1.400 to 5.450, p=0.004). The p22phox C242T gene polymorphism T allele was significantly associated with an increased risk of overt diabetic nephropathy (OR 2.760).
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