Key result
Elevated serum miR-199a-5p was an independent predictor of major adverse cardiovascular events at 6 months (HR 2.954) and, when combined with echocardiography, provided high diagnostic accuracy for acute myocardial infarction.
Why the study?
Diagnosis and prognostic evaluation of acute myocardial infarction are crucial for patients, prompting investigation into the clinical significance of serum miR-199a-5p combined with echocardiography.
Does the combination of serum miR-199a-5p and echocardiography improve the diagnosis of acute myocardial infarction and predict the occurrence of major adverse cardiovascular events?
Observational (n=140)
Single-blind
No
Does the combination of serum miR-199a-5p and echocardiography improve the diagnosis of acute myocardial infarction and predict the occurrence of major adverse cardiovascular events?
Hazard Ratio: 2.954
p-value: p=0.028
The combination of serum miR-199a-5p and echocardiographic parameters demonstrates high diagnostic accuracy for acute myocardial infarction and provides significant prognostic value for predicting 6-month major adverse cardiovascular events.
miR-199a-5p plus echocardiography may aid AMI diagnosis and MACE prediction; leaves open whether it improves outcomes over standard markers.
BACKGROUND: Diagnosis and prognostic evaluation of acute myocardial infarction (AMI) are crucial for patients. OBJECTIVE: The clinical significance of serum miR-199a-5p combined with echocardiography in AMI was investigated to provide some reference for clinical treatment. METHODS: The study subjects were 90 AMI patients and 50 acute chest pain patients (control). All patients were examined by echocardiography and recorded LVEDV, LVESV, and LVEF. RT-qPCR was performed to detect the serum miR-199a-5p level. Pearson analysis was used to analyze the correlation of miR-199a-5p with LVEF and cTnI. The diagnostic value of miR-199a-5p combined with LVEDV, LVESV, and LVEF was assessed by the ROC curve. The occurrence of major adverse cardiovascular events (MACE) was recorded to analyze the prognostic value of miR-199a-5p by the Kaplan-Meier curve and Cox regression. RESULTS: Serum miR-199a-5p was elevated in AMI, positively correlated with cTnI and negatively correlated with LVEF. The combination of miR-199a-5p with LVEDV, LVESV, and LVEF enhanced the sensitivity and specificity for the diagnosis of AMI. Patients with high miR-199a-5p expression were more likely to develop MACE. The combination of miR-199a-5p with LVEF improved the prediction of MACE. CONCLUSIONS: The combination of miR-199a-5p with echocardiography improved the diagnostic efficiency of AMI and provided prognostic information.
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Xu et al. (2025) conducted an observational in Acute myocardial infarction (n=140). Serum miR-199a-5p and echocardiography vs. Control group (non-cardiogenic chest pain) / Low miR-199a-5p expression was evaluated on Major adverse cardiovascular events (MACE) at 6 months (HR 2.954, p=0.028). Elevated serum miR-199a-5p was an independent predictor of major adverse cardiovascular events at 6 months (HR 2.954) and, when combined with echocardiography, provided high diagnostic accuracy for acute myocardial infarction.
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