Key result
A two-dimensional numerical simulation model demonstrated that ATP concentration distribution depends strongly on the internal elastic lamina pore structure, whereas LDL transport is only weakly dependent.
Population
Two-dimensional numerical simulation model of the internal elastic lamina and arterial media, including…
Design
Preclinical
Authors
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Does not alter clinical practice; leaves open in vivo validation for atherosclerosis modeling.
Computational modeling reveals that the internal elastic lamina pore structure differentially affects the transport of ATP (diffusion-limited) and LDL (convection-limited) in the arterial wall.
Tada et al. (2004) studied this question. Two-dimensional numerical simulation model of the internal elastic lamina was evaluated on Macromolecular transport and uptake (ATP and LDL) in the media. A two-dimensional numerical simulation model demonstrated that ATP concentration distribution depends strongly on the internal elastic lamina pore structure, whereas LDL transport is only weakly dependent.
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