Key result
Three-dimensional numerical simulations demonstrated that local shear stress on smooth muscle cells right beneath fenestral pores could be more than 10 times higher than on cells far from the IEL.
Population
Three-dimensional numerical simulation model of the medial layer of an artery with internal elastic lamina…
Design
Preclinical
Authors
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May implicate subendothelial shear in vascular mechanobiology; leaves open in vivo relevance and requires experimental confirmation.
3D simulations reveal that smooth muscle cells proximal to fenestral pores in the internal elastic lamina may experience shear stress levels higher than endothelial cells exposed to normal blood flow.
Tada et al. (2002) studied Arterial interstitial flow and shear stress. 3D numerical simulation of interstitial flow was evaluated on Local shear stress on smooth muscle cells (SMCs). Three-dimensional numerical simulations demonstrated that local shear stress on smooth muscle cells right beneath fenestral pores could be more than 10 times higher than on cells far from the IEL.
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