Key result
STZ-induced diabetes in rats was associated with pronounced arterial morphometric changes and increased circumferential stiffness over time, with opening angles peaking at 4 weeks (p<0.05).
p-value: p=<0.05
Experimental diabetes in rats induces significant time-dependent morphometric changes and increased arterial stiffness that correlate with accumulated serum glucose levels.
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Hypothesis-generating for hyperglycemia-driven arterial remodeling; leaves open translation to human diabetic vasculopathy.
Zhao et al. (2000) studied Diabetes (n=48). STZ-induced diabetes vs. Non-diabetic (sham injection) was evaluated on Morphometric and passive biomechanical properties of arterial walls (p=<0.05). STZ-induced diabetes in rats was associated with pronounced arterial morphometric changes and increased circumferential stiffness over time, with opening angles peaking at 4 weeks (p<0.05).
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