July 1, 1995British Journal of PharmacologyOpen Access

Effect of frusemide, ethacrynic acid and indanyloxyacetic acid on spontaneous Ca‐activated currents in rabbit portal vein smooth muscle cells

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Population

Rabbit portal vein smooth muscle cells

Design

Preclinical

Authors

IGIain A. GreenwoodSt George's, University of London RHR. C. HoggThe University of Queensland WLW. A. LargeSt George's, University of London

Discussion

Member takes

Implication

May indicate chloride current mechanism for vasodilation in animal cells; leaves open translation to human therapeutics.

Structured PICO

Population

Rabbit portal vein smooth muscle cells

Intervention

Frusemide (0.3-1.0 x 10(-3) M), ethacrynic acid (2-5 x 10(-4) M), and indanyloxyacetic acid

Outcome

Effect on spontaneous calcium-activated chloride (ICl(Ca)) and potassium currents (IK(Ca))surrogate

Frusemide and indanyloxyacetic acid directly inhibit spontaneous calcium-activated chloride currents in rabbit portal vein smooth muscle cells, suggesting a potential mechanism for their vasodilator effects.

Cite This Study

Greenwood et al. (1995) studied this question.

synapsesocial.com/papers/6a917ec8bd296d8bc5121183 https://doi.org/10.1111/j.1476-5381.1995.tb14994.x

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Effect of frusemide, ethacrynic acid and indanyloxyacetic acid on spontaneous Ca‐activated currents in rabbit portal vein smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effect of frusemide, ethacrynic acid and indanyloxyacetic acid on spontaneous Ca‐activated currents in rabbit portal vein smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider